Assuntos
Dermatomicoses/diagnóstico , Trichosporon/isolamento & purificação , Tricosporonose/diagnóstico , Antibacterianos/uso terapêutico , Antifúngicos/uso terapêutico , Pré-Escolar , Dermatomicoses/tratamento farmacológico , Dermatomicoses/microbiologia , Humanos , Masculino , Neutropenia/diagnóstico , Tricosporonose/tratamento farmacológico , Tricosporonose/microbiologiaRESUMO
Contact immunotherapy is an increasingly used, effective means of treating cutaneous viral warts. Dinitrochlorobenzene, diphencyprone, and squaric acid dibutylester are the most frequently used modalities, showing slight variances in adverse effect profiles and efficacy. All of these agents serve as safe treatment modalities when administered according to the guidelines recommended herein. We review the value of contact immunotherapy in the treatment of cutaneous viral warts.
Assuntos
Alérgenos/uso terapêutico , Ciclobutanos/uso terapêutico , Ciclopropanos/uso terapêutico , Dinitroclorobenzeno/uso terapêutico , Dermatopatias/tratamento farmacológico , Verrugas/tratamento farmacológico , Adjuvantes Imunológicos/uso terapêutico , Alérgenos/efeitos adversos , Ciclobutanos/efeitos adversos , Ciclopropanos/efeitos adversos , Dinitroclorobenzeno/efeitos adversos , HumanosRESUMO
The majority of toxic epidermal necrolysis (TEN) cases are provoked by "high risk" medications (e.g. allopurinol, aromatic anticonvulsants, nevirapine, oxicam non-steroidal anti-inflammatory agents, and sulfonamides). TEN usually occurs 1 to 8 weeks after initial administration of the offending agent, but re-administration can evoke TEN within hours to days. Hydroxychloroquine has rarely been associated with TEN, with one case proving fatal. Herein, we report a case of hydroxychloroquine-induced fatal TEN complicated by angioinvasive Rhizopus. To our knowledge, this is the first case report of angioinvasive Rhizopus in a TEN patient. Initial misidentification of the offending agent causing TEN also serves as an important teaching point worth highlighting.
Assuntos
Antirreumáticos/efeitos adversos , Hidroxicloroquina/efeitos adversos , Mucormicose/complicações , Rhizopus , Síndrome de Stevens-Johnson/etiologia , Adulto , Vasos Sanguíneos/microbiologia , Dermatoses Faciais/microbiologia , Evolução Fatal , Feminino , Humanos , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Mucormicose/microbiologia , Necrose/microbiologia , Dermatoses do Couro Cabeludo/microbiologia , Pele/patologiaAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ictiose/etiologia , Doenças Linfáticas/etiologia , Linfoma Anaplásico de Células Grandes/complicações , Linfoma Anaplásico de Células Grandes/diagnóstico , Pele/patologia , Idoso , Ciclofosfamida/administração & dosagem , Diagnóstico Diferencial , Doxorrubicina/administração & dosagem , Humanos , Ictiose/patologia , Ictiose/terapia , Linfoma Anaplásico de Células Grandes/tratamento farmacológico , Masculino , Prednisolona/administração & dosagem , Resultado do Tratamento , Vincristina/administração & dosagem , Redução de PesoRESUMO
Plaque-like cutaneous mucinosis (PCM) is a rare disorder of dermal mucin deposition. Some patients with PCM will be found to have an associated malignancy. We report the case of a 72-year-old man presenting with new onset pruritic, waxy-appearing erythematous and skin-colored papules and nodules coalescing into plaques on his shoulder, scalp, and forehead. Skin biopsy revealed cutaneous mucinosis. Despite conservative treatment, his skin lesions progressed, and he was found to have an occult malignancy of pancreatobiliary origin. After several months of chemotherapy, his skin lesions showed progressive improvement. To our knowledge, this is the third reported case of paraneoplastic PCM and the first reported to occur in association with underlying adenocarcinoma of pancreatobiliary origin. PCM may occasionally represent a paraneoplastic dermatosis. This case highlights the importance of a search for occult malignancy in such patients.
